中性粒细胞胞外诱捕网与乳腺癌相关研究进展

Research Progress on Neutrophil Extracellular Traps in Breast Cancer

中性粒细胞胞外诱捕网(neutrophil extracellular traps, NETs)是由DNA-组蛋白复合物以及被激活的中性粒细胞释放的蛋白质组成的网状结构。除了在中性粒细胞固有免疫应答中发挥关键作用外,NETs还参与自身免疫性疾病,如系统性红斑狼疮、类风湿性关节炎,以及其他非感染性病理过程,如血栓形成、糖尿病、血管炎和肿瘤。乳腺癌是全球女性中发病率最高的恶性肿瘤。NETs与乳腺癌进展、转移以及相关并发症(如静脉血栓栓塞)的发生有关。本文主要阐述NETs与乳腺癌相关的研究进展,并探讨NETs在乳腺癌临床治疗中的潜在用途。

Neutrophil extracellular traps (NETs) are net-like structures composed of DNA-histone complexes and proteins released by activated neutrophils. In addition to playing a key role in neutrophil in-nate immune responses, NETs are involved in autoimmune diseases such as systemic lupus ery-thematosus, rheumatoid arthritis, and other non-infectious pathological processes such as throm-bosis, diabetes, vasculitis, and tumor. Breast cancer is the most common malignancy among women worldwide. NETs are associated with breast cancer progression, metastasis, and related complica-tions, such as venous thromboembolism. This review will focus on the research progress of NETs and breast cancer, meanwhile discussing the potential use of NETs in the clinical treatment of breast cancer.