自噬现象在肾纤维化中的作用

The Role of Autophagy in Renal Fibrosis

肾脏纤维化是所有慢性肾病发展为终末期肾病的最终共同途径。自噬是一种高度保守的溶酶体降解途径,在维持所有主要类型的肾细胞,包括肾小管细胞、足细胞、系膜细胞和肾小球内皮细胞的维持中发挥重要作用。自噬功能障碍与各种肾脏病理的发病机制密切相关。本文,我们就自噬在肾脏固有细胞及其在相关肾脏疾病中的病理作用和调控进行综述。探讨针对自噬的途径和针对肾脏纤维化的特异治疗,来预防和治疗肾纤维化和相关肾脏疾病。

This renal fibrosis is the final common pathway by which all chronic kidney diseases develop into end-stage renal disease. Autophagy is a highly conserved lysosomal degradation pathway that plays an important role in the maintenance of all major types of renal cells, including tubular cells, podo-cytes, mesangial cells and glomerular endothelial cells. Autophagic dysfunction is closely related to the pathogenesis of various renal pathologies. In this article, we review the role and regulation of autophagy in intrinsic renal cells and related renal diseases. Objective: To explore the specific therapy for renal fibrosis and the approach to autophagy, in order to prevent and treat renal fibro-sis and related renal diseases.