肿瘤相关巨噬细胞在调控乳腺癌微环境的研究进展

Research Progress of Tumor-Associated Macrophages in the Regulation of Breast Cancer Microenvironment

肿瘤微环境(tumor microenvironment, TME)中肿瘤相关巨噬细胞(tumor-associated macrophages, TAMs)与炎症反应和恶性肿瘤之间的关系愈来愈明显。TAMs可分泌细胞因子、生长因子和复杂的炎症底物等,对肿瘤的启动、生长、侵袭和转移中起重要作用。针对TAMs进行靶向药物治疗乳腺癌将成为一个富有前景的方向。作者通过TAMs的类型和生物学特点,对乳腺癌的免疫逃逸、侵袭和转移,以及乳腺癌耐药的影响等研究进展做一综述。旨在为乳腺癌个性化治疗,提高生存质量提供新的思路和借鉴。

The relationship between tumor-associated macrophages (TAMs), inflammatory response and malignancy in tumor microenvironment (TME) is becoming more and more obvious. TAMs can secrete cytokines, growth factors and complex inflammatory substrates, which play an important role in tumor initiation, growth, invasion and metastasis. It will be a promising direction for TAMs to treat breast cancer with targeted drugs. This article reviews the research progress of immune escape, invasion and metastasis of breast cancer, as well as the influence of drug resistance of breast cancer, based on the types and biological characteristics of TAMs, aiming to provide new ideas and reference for personalized treatment of breast cancer and improve the quality of life.