自身免疫性肝病与肠道微生物发生发展及预后的关系

Relationship between Gut Microbiota and Development and Prognosis of Autoimmune Liver Disease

自身免疫性肝病(Autoimmune liver disease, AILD)是一组免疫介导的肝病,主要包括自身免疫性肝炎(Autoimmune hepatitis, AIH)、原发性胆汁性胆管炎(Primary biliary cholangitis, PBC)和原发性硬化性胆管炎(Primary sclerosing cholangitis, PSC)。AILD目前其发病机制尚不明确,大多数学者认为可能是遗传、免疫、环境等多个因素共同参与的结果。随着近几年微生物研究越来越受到学者重视,不少研究发现肠道微生物与自身免疫性肝病关系越来越密切。本文综述AILD和肠道微生物之间的关系,总结AILD中微生物的组成和功能改变,讨论肠道微生物在疾病发生和进展中的潜在作用,并为AILD的治疗方法提供新的方向。

Autoimmune liver disease (AILD) is a group of immune mediated liver diseases, mainly including Autoimmune hepatitis (AIH), Primary biliary cholangitis (PBC) and Primary sclerosing cholangitis (PSC). At present, the pathogenesis of autoimmune liver disease is not clear, and most scholars be-lieve that it may be the result of the joint participation of genetic, immune, environmental and other factors. In recent years, more and more scholars pay attention to microbial research. Many studies have found the relationship between intestinal microorganisms and autoimmune liver disease. This article summarizes the composition and functional changes of Gut microbiota, dis-cusses the potential role of Gut microbiota in disease occurrence and progression, and provides a new direction for the treatment of AILD.