血尿酸水平在心肌梗死发生发展中的研究进展

Research Progress of Serum Uric Acid in the Occurrence and Development of Myocardial Infarction

心肌梗死是一种常见的心血管疾病,多由冠状动脉闭塞、斑块破裂等使心肌细胞坏死而引起,近年来,我国心肌梗死的发病率和死亡率呈上升趋势。心肌梗死的发病率虽然与地域没有密切关系,但已发现随着年龄的增长而增加。研究表明,心肌梗死通常开始在年轻人和中年人中发展。因此,心肌梗死的预防、检测和治疗已成为医学专家学者关注的领域。尿酸是嘌呤代谢(腺嘌呤和鸟嘌呤降解)的最终产物,主要来源于内源性合成。越来越多证据表明,尿酸与高血压、糖尿病、慢性肾病和肥胖一起,被视为众所周知的心血管危险因素。最近的回顾性研究表明,高尿酸血症是急性心肌梗死患者短期和长期死亡率的独立预测因子。然而,血清尿酸升高与ST段抬高心肌梗死不良结果之间的相关性证据仍存在争议,研究显示了相互矛盾的结果。因此本文对血尿酸水平与心肌梗死的关系进行综述,以期阐明血尿酸水平在心肌梗死患者预后的重要性。

Myocardial infarction (MI) is a common cardiovascular disease caused by coronary artery occlusion and plaque rupture. In recent years, the incidence and mortality of myocardial infarction in our country increased. The incidence of MI, although not closely related to geography, has been found to increase with age. Studies have shown that MI usually begins to develop in young and middle-aged adults. Therefore, the prevention, detection, and treatment of myocardial infarction have become an area of concern for medical experts and scholars. Uric acid is the end product of purine metabolism (adenine and guanine degradation), mainly derived from endogenous synthesis. Increasing evidence suggests that uric acid, together with hypertension, diabetes, chronic kidney disease, and obesity, is seen as a well-known cardiovascular risk factor. Recent retrospective studies suggest that hyperuricemia is an independent predictor of short and long-term mortality in patients with AMI. However, the evidence for an association between elevated serum uric acid and the adverse outcome of ST elevation in MI remains controversial, with studies showing conflicting results. Therefore, this review shed lights on the relationship between blood uric acid levels and MI in order to clarify the prognostic significance of blood uric acid levels in patients with MI.