摘要
胰腺癌是一种恶性程度极高的消化道肿瘤。由于早期症状不典型,大多数患者确诊时已丧失手术机会。化疗和靶向治疗是晚期患者的首选,然而目前化疗药物毒性大,总反应率低,因此探索潜在治疗靶点迫在眉睫。TGF-β (transforming growth factor beta, TGF-β)作为一种细胞因子,在肿瘤中的作用越来越受到重视。本综述针对TGF-β在胰腺癌中的作用机制进行全面综述,并探讨其在胰腺癌治疗中的潜在可能。
Pancreatic cancer is a highly malignant tumor of the gastrointestinal tract. Due to atypical early symptoms, most patients are already lost to surgery by the time they are diagnosed. Chemotherapy and targeted therapies are the first choice for patients with advanced disease;however, the current high toxicity of chemotherapy drugs and low overall response rates make it urgent to explore potential therapeutic targets. The role of TGF-β as a cytokine in pancreatic cancer has received increasing attention. This review provides a comprehensive review of the mechanism of action of TGF-β in pancreatic cancer and explores its potential possibilities in the treatment of pancreatic cancer.
出处
《临床医学进展》
2022年第12期11405-11411,共7页
Advances in Clinical Medicine
