摘要
转录因子Y染色体上的性别决定区相关高迁移率族盒蛋白4 (sex-dertermining region of Y chromo-some related high mobility group box 4, SOX4)是SOX (SRY-box transcription factor)家族C亚群的成员,越来越多的报道称SOX4可能参与胃癌的发生及发展。研究表明,SOX4在胃癌组织中呈高表达,且SOX4的表达与胃癌的分化程度、临床分期、淋巴结转移等相关。同时,有研究表明SOX4可抑制胃癌细胞的增殖侵袭、影响患者的预后等,故SOX4有望成为胃癌肿瘤治疗的新靶点。本文就SOX4在胃癌中的作用及相关机制进行综述。
Sex-determining region of Y chromosome related high mobility group box 4 (SOX4) is a member of subgroup C of SOX (SRY-box transcription factor) family, more and more reports suggest that SOX4 may be involved in the occurrence and development of gastric cancer. Studies have shown that SOX4 is highly expressed in gastric cancer tissues, and the expression of SOX4 is related to the de-gree of differentiation, clinical stage, and lymph node metastasis of gastric cancer. At the same time, studies have shown that SOX4 can inhibit the proliferation and invasion of gastric cancer cells and affect the prognosis of patients, so SOX4 is expected to become a new target for gastric cancer tumor therapy. This article reviews the role and related mechanisms of SOX4 in gastric cancer.
出处
《临床医学进展》
2022年第12期11441-11450,共10页
Advances in Clinical Medicine
