关于自噬促进血管新生的研究

Research on Autophagy Promoting Angiogenesis

自噬是一种非选择性溶酶体降解过程,也是真核生物中一个高度保守的过程。在这个过程中,自噬将过量、受损、变性及失去功能的细胞器隔离在双膜囊泡中,并输送到溶酶体进行分解和消化,并重新回收利用降解产物,该过程会出现在多种生物当中,主要为实现细胞代谢的需要,维持细胞稳定性。而血管新生会持续发生在机体的生长发育过程,特别是在创面愈合中,血管新生是极其重要的环节,对疾病与创面愈合的影响较大。因此,对自噬促进血管新生进行深入的研究会给促进创面愈合带来新的方向与思路。

Autophagy is a non-selective lysosomal degradation process, which is also a highly conserved process in eukaryotes. In this process, autophagy insulates excess, damaged, denatured and non-functional organelles in double-membrane vesicles, and delivers them to lysosomes for decomposition and digestion and recycling of degradation products. This process can be found in a variety of organisms. Mainly for the realization of cell metabolism needs to maintain cell stability. Angiogenesis will continue to occur in the process of body growth and development, especially in wound healing, angiogenesis is an extremely important link, and has a great impact on disease and wound healing. Therefore, in-depth research on autophagy promoting angiogenesis will bring new directions and ideas for promoting wound healing.