细胞因子在肾综合征出血热中的临床应用研究进展

Research Progress of Clinical Application of Cytokines in Hemorrhagic Fever with Renal Syndrome

肾综合征出血热(HFRS)是一种由汉坦病毒(HTNV)引起,经鼠传播的自然疫源性疾病,在世界范围内流行,每年90%的病例发生在我国。HFRS感染的典型临床特征包括急性肾损伤、血小板减少和血管通透性增加。宿主免疫或炎症机制可能在毛细血管渗漏的发生中起重要作用。在评估由HTNV引起的HFRS严重程度的背景下,与免疫或炎症密切相关的细胞因子成为目前研究的热门方向。本文结合近年来国内外相关研究,阐述细胞因子与HFRS严重程度关系的研究进展及细胞因子对于HFRS严重程度的预测价值。

Hemorrhagic fever with renal syndrome (HFRS) is a natural, mouse-borne disease caused by Han-tavirus (HTNV). It is endemic worldwide, with 90% of cases occurring in China each year. Typical clinical features of HFRS infection include acute kidney injury, thrombocytopenia, and increased vascular permeability. Host immune or inflammatory mechanisms may play an important role in the development of capillary leakage. In the context of evaluating the severity of HFRS caused by HTNV, cytokines closely related to immunity or inflammation have become a hot research direction at present. In this paper, based on relevant studies at home and abroad in recent years, the research progress of the relationship between cytokines and the severity of HFRS and the predictive value of cytokines for the severity of HFRS were expounded.