幽门螺杆菌及其血清学分型在胃癌中的意义

Significance of Helicobacter pylori and Its Serological Typing in Gastric Cancer

胃癌是世界上最常见的恶性肿瘤之一。胃癌是由于多种因素的共同作用而导致,幽门螺杆菌与胃癌的发生发展密切相关,幽门螺杆菌是WHO认定的胃癌首要致癌因子,对胃癌患者的预后有着极大影响。幽门螺杆菌拥有多种毒力因子,包括细胞毒素相关蛋白(CagA)、空泡毒素相关蛋白(VacA)以及尿素酶等,基于这些毒力因子的幽门螺杆菌的血清学分型与其致病力密切相关。因此,继续研究幽门螺杆菌及其血清分型对胃癌的发生发展以及预后是相当重要的。

Gastric cancer is one of the most common malignant tumors in the world. Gastric cancer is caused by a variety of factors. Helicobacter pylori is closely related to the occurrence and development of gastric cancer. Helicobacter pylori is the primary carcinogen of gastric cancer recognized by WHO, which has a great impact on the prognosis of patients with gastric cancer. Helicobacter pylori has a variety of virulence factors, including cytotoxin associated gene A (CagA), vacuolating cytotoxin A (VacA) and urease. The serotyping of Helicobacter pylori based on these virulence factors is closely related to its pathogenicity. Therefore, it is very important to continue to study Helicobacter pylori and its serotyping for the occurrence, development and prognosis of gastric cancer.