炎症因子C-反应蛋白和白介素-6在缺血性脑卒中的研究进展

Research Progress of Inflammatory Factors C-Reactive Protein and Interleukin-6 in Ischemic Stroke

缺血性脑卒中是一种病因复杂的综合征,其中炎症反应参与其发病机制的全程。分子生物学、流行病学证据表明CRP和IL-6在脑卒中发病的病理生理机制中具有重要作用,影响缺血性卒中的发生、发展及预后。本综述从分子生物学、流行病学和新近开展的临床研究阐述CRP和IL-6在缺血性脑卒中发生发展及预后中的作用和意义。

Ischemic stroke is a syndrome with complex etiology, in which inflammatory response is involved in the whole process of its pathogenesis. Molecular biology and epidemiological evidence show that CRP and IL-6 play an important role in the pathophysiology of stroke and affect the occurrence, de-velopment and prognosis of ischemic stroke. This review summarizes the role and significance of CRP and IL-6 in the development and prognosis of ischemic stroke from the perspectives of molecu-lar biology, epidemiology and recent clinical studies.