某三甲医院内镜中心就诊人群幽门螺杆菌感染的初步研究

Preliminary Study of Helicobacter Pylori Infection in the Endoscopy Center of a Grade-A Tertiary Hospital

目的:探讨我院消化内镜中心就诊人群幽门螺杆菌(Hp)感染规律及其影响因素,为Hp感染及相关疾病的预防和诊治提供理论依据。方法:选取2019年1月至2022年2月在我院内镜中心进行Hp感染检测的10,918人作为研究对象,收集就医人群的尿素13C呼气试验资料进行统计分析,评估Hp感染的人群分布特点。结果:Hp总阳性率为44.50%;年度总Hp阳性率比较差异有统计学意义(P < 0.05),且呈先上升后逐渐下降趋势;不同性别Hp阳性率比较差异有统计学意义(P < 0.05),男性Hp感染率明显高于女性;不同年龄组受检者的Hp阳性率差异有统计学意义(P < 0.05);一天之中不同时间段的Hp阳性检出率差异有统计学意义(P < 0.05),且从清晨至傍晚随着时间推移Hp阳性检出率呈上升趋势。结论:Hp感染与生活习惯密切相关,社交活动活跃度对Hp感染有影响;一天之中不同时间段的Hp阳性率变化提示胃酸分泌规律对Hp阳性检出率有一定影响。

Objective: To study the law and influencing factors of Helicobacter pylori (Hp) infection in the popu-lation of the digestive endoscopy center of our hospital, and to provide a theoretical basis for the prevention and diagnosis of Hp infection and related diseases. Methods: The 10,918 cases of the endoscopy center of our hospital from January 2019 to February 2022 were enrolled as the subjects of study. The data of urea 13C breath test was collected for statistical analysis to assess the distribu-tional characteristics of Hp infections. Results: The overall Helicobacter pylori infection rate is 44.50%. The annual Hp infection rate showed statistical difference (P < 0.05), and showed an in-creased first and then decreased trend. The total Hp infection rate of different genders was signifi-cantly different (P < 0.05). The infection rate of Hp in male was significantly higher than that in fe-male. There was significant difference in total Hp infection rate among different ages (P < 0.05). The positive rate of Hp in different periods of the day was statistically significant (P < 0.05), and the rate of positive Hp infection increased with time from morning to night. Conclusions: HP infection is closely related to living habits, and social activity has an impact on Hp infection. The change of Hp positivity rate at different times of the day indicates that the regularity of gastric acid secretion has a certain influence on the Hp positive detection rate.