鳖甲及其复方制剂防治脏器纤维化研究进展

Progress in Prevention and Treatment of Organ Fibrosis by Turtle Shell and Its Compound Preparation

鳖甲,初次记载于《神农本草经》中,作为我国传统中药,被认为具备“滋阴潜阳,软坚散结”的功能,可与多种传统药物配伍,形成方剂,治疗不同疾病。起初并不是治疗脏器纤维化的专方,但随着药学及现代分子生物学的发展,学者们逐渐发现鳖甲及其复方制剂中的一些有效成分对于抗脏器纤维化具有积极作用,并开展了一系列研究,证实其传统功效并揭示了其包含的现代药理学基础,为临床抗脏器纤维化提供新的思路及为药物开发提供科学依据。

Turtle shell, first recorded in Shennong Ben Cao Jing, as a traditional Chinese medicine, is consid-ered to have the function of “nourishing yin and subsiding yang, softening and hardening” and can be combined with a variety of traditional drugs to form formulas and treat different diseases. At first, it is not a special prescription for the treatment of organ fibrosis, but with the development of pharmacy and modern molecular biology, scholars have gradually found that some active ingredi-ents in turtle shell and its compound preparations have a positive effect on anti-organ fibrosis, and carried out a series of studies to confirm its traditional efficacy and reveal the modern pharmaco-logical basis it contains, providing new ideas for clinical anti-organ fibrosis and providing a scientific basis for drug development.