TyG指数与IR在2型糖尿病认知障碍中的研究进展

Research Progress of TyG Index and IR in Cognitive Impairment of Type 2 Diabetes Mellitus

胰岛素抵抗(IR)是2型糖尿病(T2DM)的特征,是糖尿病慢性并发症的主要发病机理之一,在并发症到来以前准确识别IR水平至关重要。IR发生机理尚未明确,目前主要是脂质超载和炎症两种观点。甘油三酯–葡萄糖指数(TyG)是经济有效的评估IR的新型指标。近年来,该指数在T2DM、糖尿病肾病、代谢综合征、动脉粥样硬化等多种临床常见疾病中的评估作用得到证实。本文主要针对TyG指数与IR在2型糖尿病相关认知障碍(TDACD)中的研究做一综述,以期为认知障碍进展、并发症防治提供新依据,为临床早期识别和干预提供新思路。

Insulin resistance (IR) is a characteristic of type 2 diabetes mellitus (T2DM) and one of the main pathogenesis of chronic diabetes complications. It is important to accurately identify IR levels be-fore the onset of complications. The mechanism of IR is not yet clear, but lipid overload and inflam-mation are the two main ideas. Triglyceride-glucose index (TyG) is an economical and effective new index to evaluate IR. In recent years, the index has been proved to be useful in evaluating many common clinical diseases, such as T2DM, diabetic nephropathy, metabolic syndrome and athero-sclerosis. This paper mainly reviews the studies on TyG index and IR in Type 2 diabetes-related cognitive impairment (TDACD), with a view to providing a new basis for the progression of cognitive impairment and the prevention and treatment of complications, as well as new ideas for early clini-cal identification and intervention.