神经毡蛋白Neuropilin-2相关信号通路研究进展

Research Progress of Neuropeptin-2 Related Signaling Pathway

神经毡蛋白2 (Neuropilin-2, Npn-2)是Npn家族中重要成员之一,在神经系统中,Npn-2最初被认为是脑信号蛋白(Semaphorins, Sema)家族的受体,参与诱导轴突生长锥的塌陷,但随后研究发现,Npn-2也是血管内皮生长因子(VEGF)的受体,而血管内皮生长因子(VEGF)对神经元有营养作用,促进轴突的生长和迁移。此外,Npn-2还在其他疾病的发生发展中有突出作用,成为靶向治疗的热点。这篇综述着重于对近年Npn-2介导的信号通路进行一个系统的总结,其中一些神经系统外的信号通路可能给Npn-2在癫痫等神经系统疾病研究中提供思路和借鉴。

Neuropilin-2 (Npn-2) is one of the important members of the Npn family. In the nervous system, Npn-2 was initially considered to be the receptor of the brain signal proteins (Semaphorins, Sema) family and involved in inducing the collapse of the axon growth cone. However, later studies found that Npn-2 is also the receptor of vascular endothelial growth factor (VEGF), which has a nutritional effect on neurons and promotes the growth and migration of axons. In addition, Npn-2 also plays a prominent role in the occurrence and development of other diseases, becoming a hot spot of tar-geted therapy. This review focuses on a systematic summary of the signal pathways mediated by Npn-2 in recent years. Some signal pathways outside the nervous system may provide ideas and references for Npn-2 in the study of epilepsy and other nervous system diseases.