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达比加群在老年非瓣膜性房颤合并心衰患者中的临床疗效和安全性研究

Clinical Efficacy and Safety of Dabigatran in Elderly Patients with Non Valvular Atrial Fibrillation and Heart Failure
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摘要 本研究拟探讨达比加群在老年非瓣膜病性房颤合并心衰患者中的抗凝效果以及安全性,以及达比加群对不同类型、不同程度的心衰患者的抗凝效果。为这类患者优化抗凝药物选择提供临床依据。方法:选择2018年1月~2022年12月在我院门诊或住院部接受长期抗凝治疗的老年NVAF合并心衰的患者207例,分为达比加群组和华法林组。目的:探讨达比加群对高龄无瓣膜房颤伴心力衰竭的长期抗凝药效果及疗效,但其安全性显著高于华法林。 This study intends to explore the anticoagulation effect and safety of dabigatran in elderly patients with non valvular atrial fibrillation and heart failure, and the anticoagulation effect of dabigatran in patients with different types and degrees of heart failure to provide clinical basis for optimizing the selection of anticoagulant drugs for such patients. Methods: 207 elderly NVAF patients with heart failure who received long-term anticoagulation treatment in our outpatient or inpatient depart-ment from January 2018 to December 2022 were selected and divided into dabigar group and war-farin group. Objective: To investigate the long-term anticoagulant effect of dabigatran on valveless atrial fibrillation with heart failure in the elderly, but its safety is significantly higher than warfarin.
出处 《临床医学进展》 2023年第1期662-668,共7页 Advances in Clinical Medicine
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  • 1张鹤萍,胡大一.非心瓣膜疾病性心房颤动与血栓栓塞[J].中华心血管病杂志,2005,33(10):966-968. 被引量:39
  • 2黄从新,马长生,杨延宗,黄德嘉,张澍,江洪,杨新春,吴书林,马坚,刘少稳,李莉,曹克将,王方正,陈新.心房颤动:目前的认识和治疗建议(二)[J].中华心律失常学杂志,2006,10(3):167-197. 被引量:269
  • 3PRYSTOWSKY E N, BENSON DW J R, FUSTER V, et al. Management of patients with atrial fibrillation: a statement for healthcare professionals from the subcommittee on electrocardiography and electrophysiology. American Heart Association[J]. Circulation, 1996,93 : 1262-1277.
  • 4ALEXANDER G G. Turpie. New oral anticoagulants in atrial fibrillation: Department of Medicine[J]. European Heart Journal, 2008,29:155-165.
  • 5OLSSON S B, HALPERIN J L. Prevention of stroke in patients with atrial fibrillation: Department of Cardiology, University Hospital, Lund, Sweden[J]. Sevain Vase Med,2005,5:285-292.
  • 6RCIFEL J A. Will direct thrombin inhibitors replace warfarin for preveting embolic events in atrial fibrillation[J]. Curr Opin Cardiol,2004,19: 58-63.
  • 7UETRECHT J. Idiosyncratic drug reactions: past, present, and future[J]. Chem Res Toxicol, 2008,21: 84-92.
  • 8SARICH T C, WOLTZ W, ERIKSSON U G, et al. Effects of ximelagatran ,an oral direct thrombin inhibitor, inhirudin, and enoxaparin on thrombin generation and pplatelet activation in healthy male subjects [J]. J Am Coll Cardiol, 2003,41: 557-564.
  • 9DIENER H C. Stroke prevention using the oral direct thrombin inhibitor ximelagatran in patients with nonvalvular atrial fibrillation. Pooled analysis from the SPORTIF III and V studies. Department of Neurology, University of Essen, Hufelandstrasse 55, DE- 45122 Essen, Germany[J]. Cerebrovasc Dis, 2006, 21:279-293.
  • 10PETERSEN P, GRIND M, ADLER J, et al. Ximelagatran verses warfarin for stroke prevention in pa tients with nonvalvular atrial fabrillationLSPORTIF Ⅱ : a dose-guiding , tolerability and safety study[J]. J Am Cardiol,2003, 41:1445-1451.

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