微小核糖核酸在OSAHS合并2型糖尿病中的研究进展

Research Progress of microRNA in OSAHS with Type 2 Diabetes

阻塞性睡眠呼吸暂停低通气综合征是一种广泛的呼吸障碍性疾病。OSAHS的主要发病机制是慢性间歇性缺氧,长期夜间间歇性缺氧可导致夜间哮喘、猝死等风险。且慢性间歇性缺氧伴有夜间低氧血症和胸腔内压力的变化,易合并糖尿病、高血压等并发症。近年来OSAHS合并糖尿病的患者越来越多。目前该疾病的黄金标准评估为多导睡眠图,然而其局限性影响睡眠监测结果,以至于约有85%的人处于高睡眠风险呼吸暂停仍未诊断。miRNA是基因表达的关键调节因子。在要求精准医疗的时代,使用miRNA-mRNA和其他基因分析控制基因表达的调控元件,其可提示多种疾病进展和预后。

Obstructive sleep apnea hypopnea syndrome is a widespread respiratory disorder. The main path-ogenesis of OSAHS is chronic intermittent hypoxia. Long term intermittent hypoxia at night can lead to night asthma, sudden death and other risks. Chronic intermittent hypoxia is associated with nocturnal hypoxemia and changes in intrathoracic pressure, which is prone to complications such as diabetes and hypertension. In recent years, there are more and more patients with OSAHS and diabetes. At present, the gold standard of the disease is polysomnography. However, its limitations affect the sleep monitoring results, so that about 85% of the people are at high sleep risk of apnea. miRNA is a key regulator of gene expression. In the era of precision medical treatment, miR-NA-mRNA and other gene analysis are used to control the regulatory elements of gene expression, which can indicate the progress and prognosis of many diseases.