摘要
血清中的HBVRNA是肝细胞内共价环状闭合DNA (covalently closed circular DNA, cccDNA)的直接转录体,其实质是核衣壳内未经转录的前基因组RNA (pregenomic RNA, pgRNA),转而以病毒颗粒样的方式释放进入血液循环,形成“HBV RNA颗粒”。近年来许多研究表明HBV RNA在监测抗病毒治疗效果、指导停药及预测复发、预测HBeAg血清学转换等方面有重要作用,是慢性乙型病毒性肝炎的一种潜在的新兴病毒学标志物。
HBV RNA in serum is a direct transcript of covalently closed circular DNA (cccDNA) in liver cells. Its essence is untranslated pregenomic RNA (pgRNA) in the nucleocapsid, which is released into the blood circulation in a virus particle like manner, forming “HBV RNA particles”. In recent years, many studies have shown that HBV RNA plays an important role in monitoring the effect of antiviral therapy, guiding drug withdrawal, predicting relapse, and predicting HBeAg seroconversion. It is a potential emerging viral marker of chronic hepatitis B.
出处
《临床医学进展》
2023年第1期899-903,共5页
Advances in Clinical Medicine
