外泌体来源的miRNA在结直肠癌中的作用

Role of Exosome-Derived miRNA in Colorectal Cancer

外泌体是由原核细胞和真核细胞主动向外释放的脂质双分子层囊泡样结构,可携带多种特异的生物活性分子如蛋白质、脂质、miRNA和lncRNA等,进入相应的靶细胞,参与调控细胞的生理及病理功能。外泌体是将miRNA和其他活性物质运输到周围细胞的容器,外泌体介导的miRNA可参与结直肠癌的发生、侵袭和转移,并在结直肠癌诊断、预后和治疗过程中扮演重要角色。本文就外泌体来源的miRNA在结直肠癌发生发展过程中的作用、诊断、预后评估及治疗中的相关研究进展进行综述。

Exosomes are lipid bilayer vesicle-like structures actively released by prokaryotic cells and eukar-yotic cells. They can carry a variety of specific biologically active molecules such as proteins, lipids, miRNA, and lncRNA into the corresponding target cells, involved in regulating the physiological and pathological functions of cells. Exosomes are containers that transport miRNA and other active sub-stances to surrounding cells. Exosome-mediated miRNA can be involved in the occurrence, invasion and metastasis of colorectal cancer, and play an important role in the diagnosis, prognosis and treatment of colorectal cancer. This article reviews the related research progress on the role of exo-somal miRNA in the occurrence and development of colorectal cancer, diagnosis, prognosis evalua-tion and treatment.