CTHRC1在器官纤维化中的研究进展

Research Progress of CTHRC1 in the Organ Fibrosis

器官纤维化是慢性炎症性器官损伤引起的细胞异常修复,导致正常组织被含有过量细胞外基质的瘢痕组织所代替的病理过程。纤维化疾病可以累及几乎全身所有器官,器官纤维化疾病进展将导致器官功能障碍。流行病学调查发现,在发达国家,有45%的患者死于慢性纤维化疾病,全球纤维化疾病发病率和相关医疗负担正逐年升高。三螺旋重复胶原蛋白1 (CTHRC1)是一种细胞外基质糖蛋白,通常是表达在上皮–间质界面,广泛参与生长发育、损伤修复、器官纤维化、肿瘤侵袭和转移过程。转化生长因子β能与CTHRC1相互作用,通过激活成纤维细胞影响胶原表达和沉积,参与器官纤维化过程。本文就CTHRC1与器官纤维化中的关系进行综述。

Organ fibrosis is a pathological process in which chronic inflammatory organ injury causes abnor-mal cellular repair, resulting in the replacement of normal tissue with scar tissue containing excess extracellular matrix (ECM). Fibrotic disease can involve almost all organs throughout the body, and progression of organ fibrotic disease will lead to organ dysfunction. Epidemiological surveys have found that 45% of patients in developed countries die from chronic fibrotic disease, and the global incidence of fibrotic disease and associated medical burden is increasing year by year. Collagen tri-ple helix repeat containing-1 (CTHRC1) is an extracellular matrix glycoprotein that is normally ex-pressed at the epithelial-mesenchymal interface and is widely involved in growth and development, injury repair, organ fibrosis, tumor invasion and metastasis processes. Transforming growth factor β (TGF-β) can interact with CTHRC1 to affect collagen expression and deposition through activation of fibroblasts and participate in the organ fibrosis process. This article provides a review of the rela-tionship between CTHRC1 and organ fibrosis.