细胞间相互作用在血管钙化发病机制中的研究进展

Research Progress of Intercellular Interaction in the Pathogenesis of Vascular Calcification

血管钙化是目前心血管疾病的重要危险因素。内皮细胞(ECs)和血管平滑肌细胞(VSMCs)在这一过程中发挥着重要的作用。在炎症、剪切应力、高磷、高糖等刺激下,VSMCs会发生成骨样分化,促进钙化的形成,这是血管钙化过程中的关键环节。同时,内皮细胞、巨噬细胞、周细胞等在炎症、高磷、高糖等刺激下发挥促VSMCs钙化的作用。本文主要以血管钙化中VSMCs成骨样分化及ECs、周细胞、巨噬细胞发挥促VSMCs钙化的机制展开概述。

Vascular calcification is an important risk factor for cardiovascular diseases. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) play an important role in this process. Under the stimu-lation of inflammation, shear stress, high phosphorus and high glucose, VSMCs will undergo osteo-genic differentiation and promote the formation of calcification, which is a key link in the process of vascular calcification. At the same time, endothelial cells, macrophages and pericytes play a role in promoting the calcification of VSMCs under the stimulation of inflammation, high phosphorus and high glucose. In this paper, the osteogenic differentiation of VSMCs in vascular calcification and the mechanism of ECs, pericytes and macrophages in promoting VSMCs calcification were summarized.