创伤性颅脑损伤神经炎症预后标志物研究进展

Research Progress on Prognostic Markers of Neuroinflammation in Traumatic Head Injury

创伤性颅脑损伤在全世界范围内,都是导致患者死亡或致残的主要原因之一。脑外伤导致的神经炎症是大脑或脊髓细胞损伤的反应。神经炎症是一种复杂的现象,涉及大脑内神经免疫细胞和胶质细胞(例如星形胶质细胞和小胶质细胞),它们通过产生和释放细胞因子和炎症介质来被激活并对损伤做出反应。这些细胞因子与脑损伤部位的白细胞一起,促进了对损伤的协调反应。本文就创伤性颅脑损伤后的神经炎症阶段有价值的生物标志物对预后的研究进展进行综述。

Traumatic head injury is one of the leading causes of death or disability worldwide. Neuroinflam-mation from traumatic brain injury is a response to injury to brain or spinal cord cells. Neuroin-flammation is a complex phenomenon involving neuroimmune cells and glial cells (such as astro-cytes and microglia) within the brain that are activated and respond to damage by producing and releasing cytokines and inflammatory mediators. These cytokines, along with white blood cells at the site of brain injury, promote a coordinated response to injury. This article reviews the research progress of valuable biomarkers for prognosis in the neuroinflammatory stage after traumatic head injury.