H型高血压并阻塞性睡眠呼吸暂停低通气综合征的研究进展

Research Progress of H-Type Hypertension with Obstructive Sleep Apnea Hypopnea Syndrome

H型高血压是指伴有血浆同型半胱氨酸(homocysteine, Hcy)升高(血浆Hcy ≥ 10 μmol/L)的高血压,阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea hypopnea syndrome, OSAHS)是指由于自身上气道出现了反复塌陷,从而导致睡眠呼吸暂停、高碳酸血症、间歇性缺氧及睡眠结构紊乱等一系列病理生理改变。H型高血压与OSAHS均和多种心脑血管等疾病的发生密切相关,且相互作用。早期有效地筛查、诊断H型高血压并OSAHS患者,科学评估其风险程度,及时干预可有效预防或减少靶器官损害及心脑血管事件的发生。

H-type hypertension refers to hypertension with elevated plasma homocysteine (Hcy) (plasma Hcy ≥ 10 μmol/L), obstructive sleep apnea hypopnea syndrome (OSAHS) refers to a series of patho-physiological changes such as sleep apnea, hypercapnia, intermittent hypoxia and sleep structure disorders due to repeated collapse of its upper airway. H-type hypertension and OSAHS are closely related to the occurrence of a variety of cardiovascular and cerebrovascular diseases, and interact. Early and effective screening and diagnosis of patients with H-type hypertension and OSAHS, scien-tific assessment of their risk degree, and timely intervention can effectively prevent or reduce the occurrence of target organ damage and cardiovascular and cerebrovascular events.