肠道微生物群与2型糖尿病并发症的关系

Relationship between Intestinal Microbiota and Complications of Type 2 Diabetes

2型糖尿病(T2DM)是世界上常见的代谢性疾病之一,其发病率和流行率仍在不断上升。研究发现,肠道微生物群失调与代谢综合征之间存在紧密联系。肠道微生物群组成的改变与2型糖尿病及其并发症的发生及进展有着密切关系,肠道微生物群能够通过降低葡萄糖耐量来改善胰岛素抵抗。在本篇综述中,我们探讨了肠道微生物群紊乱与2型糖尿病进展及主要糖尿病大血管并发症(冠状动脉疾病)和微血管并发症(肾病、视网膜病变和神经病变)的改变,并探索通过肠道微生物群与益生菌为2型糖尿病及其并发症的治疗提供新的治疗策略。

Type 2 diabetes (T2DM) is one of the most common metabolic diseases in the world, and its inci-dence rate and prevalence are still rising. Studies have found that there is a close relationship be-tween intestinal microbiota disorder and metabolic syndrome. The change of intestinal microbiota composition is closely related to the occurrence and progress of type 2 diabetes and its complica-tions. The intestinal microbiota can improve insulin resistance by reducing glucose tolerance. In this review, we discussed the progress of intestinal microbiota disorder and type 2 diabetes, and the changes of major vascular complications (coronary artery disease) and microvascular complica-tions (kidney disease, retinopathy and neuropathy) of diabetes, and explored new treatment strat-egies for type 2 diabetes and its complications through intestinal microbiota and probiotics.