端粒维持在神经母细胞瘤发病机制中的研究进展

Research Progress of Telomere Maintenance in the Pathogenesis of Neuroblastoma

端粒被广泛认为是细胞的“有丝分裂钟”,并作为生物衰老的标志而存在。保持端粒长度高于临界阈值是恶性肿瘤细胞永生的关键,也是成人和儿童癌症发生的关键因素。最新研究显示神经母细胞瘤中端粒的维持(TMM),无论是由端粒酶或ALT激活,都是神经母细胞瘤(NB)高危疾病的决定性标志。本文对端粒异常在神经母细胞瘤发病机制中的作用进行总结,为神经母细胞瘤疾病的临床诊治提供新的研究方向。

Telomeres are widely regarded as the “mitotic clock” of the cell and serve as markers of biological aging. Keeping telomere length above the critical threshold is the key to the immortalization of ma-lignant tumor cells and a key factor in the development of cancer in adults and children. Recent studies have shown that telomere maintenance in neuroblastoma, whether activated by telomerase or ALT, is a definitive marker of neuroblastoma risk disease. This article summarizes the role of te-lomere abnormalities in the pathogenesis of neuroblastoma and provides a new research direction for the clinical diagnosis and treatment of neuroblastoma disease.