小肠细菌过度生长与甲烷关系的研究

The Relationship between Methane and Small Intestine Bacterial Overgrowth

目的:探究小肠细菌过度生长与甲烷的关系。方法:回顾性分析136例行甲烷氢呼气试验的患者,分为小肠菌过度生长阳性组68例和阴性组68例,计算两组在不同时间段甲烷气和氢气的平均丰度值并绘制曲线图,比较两组值、曲线所呈现出的特征。结果:在SIBO阴性患者中,甲烷基线水平往往高于氢气基线。相反,SIBO阳性患者的甲烷基线水平往往低于氢气基线水平。两者差异有统计学意义。结论:小肠细菌过度生长可能是由于肠道内产甲烷菌不足,应当为甲烷菌生长提供有利环境。

Objective: To investigate the relationship between methane and small intestinal bacterial over-growth. Methods: Retrospective analysis was performed on 136 patients who underwent the lactu-lose methane breath test, and they were divided into a positive group of 68 cases and a negative group of 68 cases. The average abundance values of methane gas and hydrogen in the two groups at different time periods were calculated, and the curves were drawn to compare the characteristics presented by the values and curves of the two groups. Results: In SIBO-negative patients, baseline methane levels tended to be higher than baseline hydrogen. In contrast, baseline methane levels in SibO-positive patients tended to be lower than baseline hydrogen levels. The difference was statis-tically significant. Conclusion: The lack of methanogens in the intestinal tract may cause small in-testinal bacterial overgrowth. A favorable environment should be provided for methanogens to grow.