宫颈鳞状上皮内病变环形电切术后HPV持续感染的相关因素分析

Analysis of Factors Associated with Persistent HPV Infection after Loop Eelectrosurgical Excision Procedure of Cervical Intraepithelial Lesions

人乳头瘤病毒(HPV)感染是宫颈癌的主要病因,宫颈上皮内瘤变(CIN)是宫颈癌的癌前病变,可分为CIN I、CIN II和CIN III。国内对CIN II+的患者主要行手术治疗,宫颈环形电切术(Loop Eelectrosurgical Excision Procedure, LEEP)是现阶段治疗CIN的主要手段之一,应用较为广泛,在临床上取得了一定的疗效。然而依旧存在大量LEEP术后HPV依旧持续感染的问题,导致病变复发甚至进展至宫颈癌阶段,因此分析其影响因素是急需解决的问题。目前依旧有很多不确定因素,现对于已有相关研究做一篇综述。

Human papillomavirus (HPV) infection is a major cause of cervical cancer and cervical intraepitheli-al neoplasia (CIN) is the early stage of cervical cancer. It can be divided into CIN I, CIN II and CIN III. Domestic CIN II and above patients are mainly taken for surgical treatment. Loop Eelectrosurgical Excision Procedure (LEEP) is one of the most important means to treat CIN at this stage, which is widely used and has achieved certain clinical effect. However, there are still a large number of HPV persistent infections after LEEP, which lead to disease recurrence and even progress to cervical cancer. Therefore, the analysis of the influencing factors is an urgent problem to be solved. There still have a lot of uncertain factors, thus to do a review of the existing relevant research.