血小板减少首发的IgG4相关性疾病1例报道

IgG4-Associated Disease That Starts with Thrombocytopenia: A Case Report

IgG4相关性疾病(IgG4-RD)是一种较为罕见的免疫介导的慢性炎症性疾病,目前确切的病因及发病机制尚不清楚,我国尚无流行病学数据,临床表现多样,可累及全身多个器官组织,糖皮质激素为该病的一线治疗药物。该文报道1例以血小板减少为首发症状的IgG4-RD男性患者,因四肢指(趾)端散发性瘀斑1月入院,经糖皮质激素治疗后,复查血小板逐步上升,未再有出现瘀点瘀斑,随访情况稳定。

IgG4-associated disease (IgG4-RD) is a rare immune-mediated chronic inflammatory disease. The exact etiology and pathogenesis of IGG4-RD are still unclear, and there are no epidemiological data in China. The clinical manifestations are diverse and can involve multiple organs and tissues in the whole body. Glucocorticoid is the first-line treatment for this disease. In this paper, a male IgG4-RD patient with thrombocytopenia as the first symptom was admitted to hospital for sporadic ecchy-mosis on the fingers (toes) of the limbs for 1 month. After glucocorticoid therapy, the platelet grad-ually increased and no petechial ecchymosis appeared again. The follow-up was stable.