2型糖尿病认知功能障碍影响因素的研究进展

Progress on Factors Influencing Cognitive Dysfunction in Patients with Type 2 Diabetes

随着生活水平提高和人口老龄化进程加速,2型糖尿病患病率日益增高。认知功能障碍是2型糖尿病的慢性并发症,导致患者的记忆力、理解力下降,空间定位障碍,严重影响患者的自理能力和生活质量。血糖、炎症、降糖药物、情绪、高血压、高脂血症和同型半胱氨酸被认为是2型糖尿病患者认知功能障碍的影响因素,其中部分由于评价指标和混杂因素的影响还有较大争议,因此,本文针对上述因素进行综述,为2型糖尿病认知功能障碍患者早期发现、早期治疗提供参考,对预防老年痴呆、延缓痴呆进程、提高患者的生活质量具有重大意义。

With the improvement of living standards and the acceleration of population aging process, the prevalence of type 2 diabetes is increasing. Cognitive dysfunction is a chronic complication of type 2 diabetes, which leads to decreased memory and comprehension and spatial positioning impairment, which seriously affects their self-care ability and quality of life. Blood glucose, inflammation, hypo-glycemic drugs, mood, hypertension, hyperlipidemia and homocysteine are considered to be the in-fluencing factors of cognitive dysfunction in type 2 diabetes patients, and part of them due to the evaluation index and confounding factors are more controversial;therefore, this review for the above factors, for type 2 diabetes patients early detection, early treatment, is of great significance to prevent senile dementia, dementia process, improve the quality of life of patients.