子宫内膜癌分子分型相关的研究进展

Research Progress on Molecular Typing of Endometrial Carcinoma

子宫内膜癌是常见的妇科肿瘤之一,分子生物学特征是肿瘤发生机制及治疗方法的研究热点,子宫内膜癌分子分型的提出为患者诊断、治疗及预后判断提供了有力依据。它的改良方法主要有前瞻性分子危险分类法(Proactive Molecular Risk Classifier for Endometrial Cancer, ProMisE)和Tans-PORTEC分型,这两种改良方法在临床工作中较为实用,患者通过分子分型可获得个体化的综合治疗方案。本文就分子分型相关的研究进展等进行综述。

Endometrial carcinoma is one of the common gynecological tumors. Molecular biological character-istics are the research focus of tumorigenesis and treatment. The proposal of molecular classifica-tion of endometrial carcinoma provides a strong basis for diagnosis, treatment and prognosis of pa-tients. Its improved methods are mainly prospective molecular risk classification (Proactive Molec-ular Risk Classifier for Endometrial Cancer, ProMisE) and Tans-PORTEC typing. These two improved methods are more practical in clinical work, and individual comprehensive treatment can be ob-tained by molecular typing. The research progress related to molecular typing is reviewed in this paper.