子宫内膜异位症免疫相关发病机制及治疗研究进展

Research Progress on the Immune-Related Pathogenesis and Treatment of Endometriosis

子宫内膜异位症(endometriosis, EMs)是一种常见的慢性妇科疾病,其发病机制仍有争议,免疫力改变以及化生子宫内膜异位部位内的细胞因子是可能的关键因素。异位子宫内膜病理性生长是局部盆腔炎症过程,可导致某些免疫相关细胞的功能改变,这些细胞释放某些生长因子,导致子宫内膜斑块改变的进展。EMs类似于具有自身免疫背景和免疫抑制机制崩溃的免疫依赖性疾病。免疫学研究可能为发现EMs的创新免疫调节疗法开辟一条新途径。本文针对EMs相关免疫细胞功能及其改变、细胞因子、最新免疫治疗方法进行阐述,希望对进一步了解子宫内膜异位症发病机制及诊治提供帮助。

Endometriosis (EMs) is a common chronic gynecological disease, and its pathogenesis is still con-troversial, and immune alteration and cytokines in metaplasia endometriosis sites are possible key factors. Ectopic pathological growth of the endometrium is a local pelvic inflammatory process that can lead to changes in the function of certain immune-related cells that release certain growth fac-tors, leading to the progression of endometrial plaque changes. EMs resembles an im-mune-dependent disease with an autoimmune background and collapse of immunosuppressive mechanisms. Immunology research may open up a new avenue for the discovery of innovative im-munomodulatory therapies for EMs. This article focuses on the function and changes of immune cells related to EMs, cytokines, and the latest immunotherapy methods, hoping to further under-stand the pathogenesis and diagnosis and treatment of EMs.