抗LGI1抗体相关脑炎合并葡萄膜炎一例并文献分析

Anti-LGI1 Antibody-Associated Encephalitis Combined with Uveitis: A Case and Literature Review

目的:我们旨在通过总结1例抗LGI1抗体相关脑炎合并葡萄膜炎的临床表现和辅助检查等特点,以提高临床医生对疾病的认识。方法:回顾性分析了1例抗LGI1抗体相关脑炎合并葡萄膜炎的临床资料,并进行了文献复习。结果:患者为中年男性,既往葡萄膜炎病史,以意识障碍、认知下降、顽固性低钠血症、面–臂肌张力障碍发作为主要临床表现,颅脑磁共振提示海马、颞叶等脑组织多发异常信号,血清抗体检测发现LGI1抗体阳性。诊断明确后给予患者激素联合丙种球蛋白治疗,上述症状均较前好转。结论:LGI1抗体脑炎常合并其他自身免疫性疾病,它应该被进一步的检测。

Objective: We aimed to improve clinicians’ understanding of the disease by summarizing the clini-cal manifestations and ancillary tests of one case of anti-LGI1 antibody-associated encephalitis with uveitis. Methods: The clinical data of one case of anti-LGI1 antibody-associated encephalitis com-bined with uveitis were retrospectively analyzed, and the literature was reviewed. Results: The pa-tient is a middle-aged man with a history of previous uveitis, who presented with impaired con-sciousness, cognitive decline, intractable hyponatremia, and face-brachial dystonia. Cranial mag-netic resonance showed multiple abnormal signals in brain tissues such as hippocampus and tem-poral lobe, and serum antibody testing is positive for LGI1 antibodies. After the diagnosis was clear, the patient was given hormone plus gamma globulin therapy, and the above symptoms were better than before. Conclusion: LGI1 antibody encephalitis is often associated with other autoimmune dis-eases, which should be further tested.