肺移植后原发性移植物功能障碍相关因素的研究进展

Research Progress on Factors Related to Primary Graft Dysfunction after Lung Trans-plantation

肺移植是目前终末期肺疾病可供选择的唯一有效方法。然而,与肝移植和肾移植相比,肺移植的短期和长期效益仍不尽人意。其中,原发性移植物功能障碍(PGD)是影响肺移植患者预后和生活质量的重要原因之一。当前,临床上PGD的治疗仍缺乏相关有效手段。如何防治PGD成为器官移植和普胸外科领域的热点。近年来,随着多中心肺移植的相继开展,PGD的认识也逐渐加深。本文就PGD的危险因素、预测指标及新兴防治方向,作一综述。以期为临床医生提供参考。

Lung transplantation is the only effective option for end-stage lung disease. However, the short- and long-term benefits of lung transplantation compared to liver transplantation and kidney trans-plantation remain unsatisfactory. Among them, primary graft dysfunction (PGD) is one of the im-portant factors affecting the prognosis and quality of life of lung transplant patients. At present, there is still a lack of relevant effective methods for the treatment of PGD in clinical practice. How to prevent PGD has become a hot spot in the field of organ transplantation and general thoracic sur-gery. In recent years, with the development of multi-center lung transplantation, the understanding of PGD has gradually deepened. This article reviews the risk factors, predictors and emerging pre-vention and treatment directions of PGD in order to provide a reference for clinicians.