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卵巢Brenner瘤的临床特点

Clinical Characteristics of Brenner Tumors of the Ovary
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摘要 卵巢Brenner瘤是一种较为罕见的肿瘤,其占所有卵巢上皮性肿瘤的不到5%。目前,卵巢Brenner瘤的起源仍不清楚,最近研究提示BT通过输卵管浆膜间皮和输卵管上皮交界处起源于输卵管,并具有雄激素刺激的额外作用。卵巢Brenner瘤多为良性肿瘤,恶性肿瘤不到2%。大多良性Brenner瘤为术前体检偶然发现,其临床表现亦无特异性。诊断主要通过病理学检查。影像学检查中钙化是其特征性表现。治疗方法主要是手术治疗,恶性患者术后可辅以化疗。紫杉醇 + 铂类是首选方案。晚期恶性患者复发较常见。对于恶性Brenner瘤的转化通路,目前已提出的有FGFR3和MDM2/TP53。其具体作用机制仍需进一步研究。 Brenner tumor (BT) of the ovary is a rare tumor, accounting for less than 5% of all epithelial tumors of the ovary. Currently, the origin of Brenner tumor (BT) of the ovary remains unclear, but recent studies suggest that BT originates from the fallopian tube through the serosal mesothelial and epi-thelial junction of the fallopian tube, with the additional effect of androgen stimulation. Brenner tumor of the ovary is mostly benign and less than 2% malignant. Most benign Brenner tumors were found accidentally by preoperative physical examination, and their clinical manifestations were nonspecific. Diagnosis is mainly through pathological examination. Calcification was the character-istic feature of imaging examination. The main treatment method is surgical treatment, malignant patients can be supplemented by chemotherapy. Paclitaxel and Platinum is the preferred solution. Relapse is more common in advanced malignant patients. For the transformation pathway of ma-lignant Brenner tumors, FGFR3 and MDM2/TP53 have been proposed. The specific mechanism of action still needs further study.
出处 《临床医学进展》 2023年第3期2985-2994,共10页 Advances in Clinical Medicine
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