伴中央–颞区棘波的自限性癫痫发病机制、共患病及药物治疗进展

Progress in Pathogenesis, Comorbidity and Drug Treatment of Self-Limited Epilepsy with Centrotemporal Spikes

伴中央–颞区棘波的自限性癫痫是儿童最常见的癫痫综合征,以自限性癫痫发作为主要特征,可伴有不同程度的精神、行为及认知障碍。其发病机制可能与遗传因素、大脑微结构损伤、大脑功能网络受损等相关,同时其可合并行为认知等方面并发症,对于患者生活质量有不同程度的影响,抗发作药物治疗的时机、方案还缺乏可靠证据支持。本文通过对伴中央颞区棘波的自限性癫痫最新文献查阅,拟对其发病机制、共患病及治疗方案做一综述。

Self-limiting epilepsy with centrotemporal spikes is the most common epilepsy syndrome in chil-dren, with self-limited seizures as the main feature, and can be accompanied by different levels of mental, behavioral and cognitive disorders. Its pathogenesis may be related to genetic factors, brain micro-structure damage, brain functional network damage, etc. At the same time, it can be combined with behavioral cognitive and other complications, which have different degrees of im-pact on the quality of life for patients. The timing and plan of anti-epileptic drug treatment still lack reliable evidence support. This article reviews the pathogenesis, comorbidity and treatment of self-limited epilepsy with central temporal spikes by reviewing the latest literature.