空洞型肺结核的相关研究进展

Research Progress of Cavitary Pulmonary Tuberculosis

肺空洞是结核病(TB)中最常见的临床特征之一。有大量文献对空洞型肺结核相关的潜在危险因素进行研究,本文就目前提出的一些潜在危险因素进行综述。根据本文中总结,DM (糖尿病)、结核分枝杆菌(MTB)载量、结核分枝杆菌(MTB)的耐药性以及吸烟作为空洞型肺结核疾病的潜在危险因素,与结核性空洞的发生、发展相互关联,互相影响。随着对空洞型肺结核临床相关因素的研究不断地深入,使我们能够确定导致空洞疾病风险增加的分子因素,让我们可以通过对早期存在危险因素的人群进行干预,以降低空洞型肺结核的发病率。

Pulmonary cavity is one of the most common clinical features of tuberculosis. There are a large number of literatures on the potential risk factors related to cavitary pulmonary tuberculosis. This article reviews some potential risk factors proposed at present. According to the summary in this article, DM (diabetes), bacterial load, drug resistance of tuberculosis bacteria and smoking, as potential risk factors of cavitary pulmonary tuberculosis disease, are related to and affect the oc-currence and development of tuberculous cavities. With the continuous deepening of the research on clinical related factors of cavitary pulmonary tuberculosis, we can determine the molecular factors that lead to the increased risk of cavitary disease, so that we can reduce the incidence rate of cavitary pulmonary tuberculosis by intervening the population with early risk factors.