多模态监测在脓毒症相关性脑病中的研究进展

Research Progress of Multimodal Monitoring in Sepsis-Associated Encephalopathy

脓毒症相关性脑病(Sepsis Associated Encephalopathy, SAE)是一种弥漫性脑功能障碍,继发于体内感染,却无明显的中枢神经系统感染。SAE急性期以意识和精神状态改变为主要特征,与幸存者的不良预后相关,目前仍缺乏有效的诊断方法。SAE患者病死率及相关并发症的增加会给家庭带来严重的经济负担,而单一的监护方式无法对SAE进行早期的预警及诊断。大脑的多模态监测可从多层面、多角度对脓毒症患者的大脑进行评估,本文拟对脓毒症相关性脑病多模态监测的研究进展进行综述,以提高人们对脓毒症相关性脑病的认识与诊治水平。

Sepsis associated encephaloopathy (SAE) is a diffuse brain dysfunction caused by internal infection and is without central nervous system infection. The acute phase of SAE, characterized by delirium and altered consciousness, is associated with poor prognosis in survivors. There are still few effec-tive diagnostic methods. The increase in case fatality and related complications in patients with SAE may impose a serious financial burden to families, and a single monitoring method cannot provide early warning and diagnosis of SAE. Multimodal monitoring can evaluate the brain of sepsis patients from multiple levels and perspectives, and this article intends to review the research progress of multimodal monitoring of sepsis-related encephalopathy to improve people’s understanding, diag-nosis and treatment of sepsis-related encephalopathy.