TP53基因异常在骨肉瘤中的研究进展

Research Progress of TP53 Gene Abnormality in Osteosarcoma

TP53基因被认为是一种有效的肿瘤抑制因子,它可以显著降低50%以上的恶性肿瘤的发病率。此外,TP53基因还可以调节细胞周期的启动,对DNA自我修复能力起着提升作用,当野生型TP53基因(Wtp53)失活时,其调控机制的效率随着突变型TP53基因(Mtp53)的增加而降低或丧失,致细胞进入S期,细胞分裂增殖,最终导致恶变细胞数量增加。TP53基因异常最早在骨肉瘤中被发现,且有着较高的发生率。本研究综述了骨肉瘤患者TP53基因异常与临床病理特征的关系,分析了TP53基因异常在骨肉瘤化疗疗效和预后中的价值。

TP53 gene is considered to be an effective tumor suppressor, which can significantly reduce the in-cidence of malignant tumors by more than 50%. In addition, TP53 gene can regulate the initiation of cell cycle and improve the self-repair ability of DNA. When wild-type TP53 gene (Wtp53) is inac-tivated, the efficiency of its regulatory mechanism decreases or loses with the increase of mutant TP53 gene (Mtp53), causing cells to enter S phase, cell division and proliferation, and finally lead to an increase in the number of malignant cells. TP53 gene abnormality was first found in osteosar-coma, and has a high incidence. This study reviewed the relationship between TP53 gene abnor-mality and clinicopathological features in patients with osteosarcoma, and analyzed the value of TP53 gene abnormality in chemotherapy efficacy and prognosis of osteosarcoma.