自身免疫特征间质性肺病研究进展

Advances in Clinical Research of Interstitial Lung Disease with Autoimmune Characteristics

具有自身免疫特征的间质性肺病(IPAF)是一组在自身免疫抗体和肺部高分辨CT上都具有典型的结缔组织病(CTD)临床表现的疾病。在间质性肺病(ILD)的临床诊断和治疗中,发现有相当数量的患者同时具有类风湿免疫病的自身抗体和肺部CT表现,但却不符合CTD的诊断标准。2015年,IPAF的诊断标准出台,为管理和分类这些患者确立了方向和参考标准。本文回顾了IPAF在诊断标准、临床特征和治疗方面的研究进展。

Interstitial lung disease with autoimmune features (IPAF) is a group of diseases with typical clinical manifestations of connective tissue disease (CTD) on both autoimmune antibodies and high- resolu-tion CT of the lung. In the clinical diagnosis and treatment of interstitial lung disease (ILD), it is found that a considerable number of patients have both autoantibodies of rheumatoid immune disease and lung CT manifestations, but they do not meet the diagnostic criteria of CTD. In 2015, diagnostic criteria for IPAF were introduced, which established direction and reference standards for the management and classification of these patients. This article reviews the advances in diag-nostic criteria, clinical features, and treatment of IPAF.