细菌性阴道病与HPV感染及宫颈病变的相关性

Correlation between Bacterial Vaginosis, HPV Infection and Cervical Lesions

细菌性阴道病(Bacterial Vaginosis, BV)是育龄妇女最常见的下生殖道感染,多见于感染人乳头瘤病毒的妇女。但是,BV、HPV和宫颈病变发展的相关性仍不明确。近年来研究发现BV可以通过破坏机体免疫调节机制持续的HPV感染会导致宫颈上皮内瘤变和宫颈癌。传统的抗生素治疗BV虽然见效快,但是治愈率低,复发率高。目前,益生菌通过重塑女性阴道微生态环境成为一种新的疗法。因此通过改善阴道微生态失调来调节机体对于HPV感染的免疫反应进而可能成为预防宫颈上皮内瘤变以及宫颈癌发生。

Bacterial vaginosis (BV) is the most common lower genital tract infection among women of childbearing age. It is most common among women infected with human papillomavirus. However, the correlation between BV, HPV and the development of cervical lesions is still unclear. In recent years, studies have found that BV can cause cervical intraepithelial neoplasia and cervical cancer by destroying the immune regulation mechanism of the body. Although the traditional antibiotic treatment of BV is effective, the cure rate is low and the recurrence rate is high. At present, probiotics have become a new therapy by reshaping the female vaginal micro-ecological environment. Therefore, it is possible to prevent cervical intraepithelial neoplasia and cervical cancer by improving the immune response to HPV infection by improving the vaginal micro-ecological imbalance.