摘要
异基因造血干细胞移植(allo-HSCT)是再生障碍性贫血的重要治疗方法。常见的并发症是机会性感染和移植物抗宿主病(GVHD)。巨细胞病毒(CMV)是机会性感染最常见的原因之一,也是导致移植相关发病率和死亡率的重要原因。本文报道一例肝炎后再生障碍性贫血行异基因造血干细胞移植(亲缘半相合)术后巨细胞病毒感染所致重症肺炎导致死亡的患儿。给予早期、足量、联合、长期的抗病毒治疗后,仍不能阻止病毒在体内的复制,最终导致死亡。
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for aplastic anemia. Common complications are opportunistic infections and graft-versus-host disease (GVHD). Cytomegalovirus (CMV) is one of the most common causes of opportunistic infection and is an important cause of transplant-related morbidity and mortality. In this paper, a child with severe pneumonia due to cytomegalovirus infection following an allogeneic hematopoietic stem cell transplantation (relatives semi-conjugated) is reported in post-hepatitis aplastic anemia. After giving early, adequate, combined, long-term antiviral therapy, it still cannot stop the replication of the virus in the body, which eventually leads to death.
出处
《临床医学进展》
2023年第3期3907-3910,共4页
Advances in Clinical Medicine
