NLRP3炎性小体与MDSC在骨髓增生异常综合征中的作用及研究进展

The Role and Research Progress of NLRP3 Inflammasome and MDSC in Myelodysplastic Syndrome

NLRP3炎症小体是近年来研究较为深入的炎症复合体之一,其不仅在各种炎性疾病中发挥重要作用,而且与肿瘤的发生发展有密切关系。髓源性抑制细胞(MDSCs)是肿瘤微环境的主要组成部分,有强大的免疫抑制活性,在肿瘤、感染和炎症中可异常增多,有效抑制T细胞、B细胞对肿瘤的杀伤,与骨髓增生异常综合征(MDS)的发生发展密切相关。最新研究表明,NLRP3炎症小体的效应因子IL-1β可招募大量的髓源性抑制细胞(MDSCs)到肿瘤部位,协助肿瘤细胞逃避免疫监测,促进肿瘤的发展。本文就NLRP3炎症小体与MDSC在MDS发病过程中的作用及研究进展作一综述。

NLRP3 inflammasome are one of the inflammatory complexes that have been intensively studied in recent years. They not only play an important role in various inflammatory diseases, but also have a close relationship with the occurrence and development of tumors. Myeloid-derived suppressor cells (MDSCs) are the main components of tumor microenvironment. They have strong immunosuppressive activity and can increase abnormally in tumor, infection and inflammation. They can effectively inhibit the killing of tumor by T cells and B cells, and are closely related to the occurrence and development of myelodysplastic syndrome (MDS). Recent studies have shown that IL-1β, an effector of NLRP3 inflammatory vesicles, recruits large numbers of myeloid-derived sup-pressor cells (MDSCs) to tumour sites, assisting tumour cells to evade immune surveillance and promoting tumour progression. This article reviews the role and research progress of NLRP3 inflammasome and MDSC in the pathogenesis of MDS.