TIPS治疗肝硬化门静脉高压及其并发症的研究现状

Research Status of TIPS in the Treatment of Portal Hypertension and Its Complications in Cirrhosis

肝硬化门静脉高压的临床主要表现为腹水、食管胃静脉曲张(gastroesophageal varices, GOV)、食管胃静脉曲张破裂出血(esophagogastric variceal bleeding, EVB)和肝性脑病等。经颈静脉肝内门体分流术(transjugular intrahepatic portosystemic shunt, TIPS)是经颈静脉入路,通过在肝静脉与门静脉之间的肝实质内建立分流道,从结构上显著降低门静脉阻力,治疗门静脉高压相关并发症的微创介入技术。本文综合近年来国内外关于TIPS治疗肝硬化门静脉高压的最新研究进展。阐述了目前TIPS治疗的适应症、禁忌症、并发症及发展展望。

The clinical manifestations of portal hypertension in cirrhotic patients were ascites, gastroesopha-geal varices (GOV), esophagogastric variceal bleeding (EVB) and hepatic encephalopathy, etc. Transjugular intrahepatic portosystemic shunt (TIPS) is a transjugular approach that significantly reduces portal resistance structurally by establishing shunt in the hepatic parenchyma between the hepatic vein and the portal vein. Minimally invasive interventional techniques for the treatment of portal hypertension related complications. In this paper, the latest research progress of TIPS in the treatment of portal hypertension in cirrhosis is summarized. The indications, contraindications, complications and development prospects of TIPS therapy were described.