MicroRNA在主动脉夹层发病机制中研究进展

Research Progress of MicroRNA in the Pathogenesis of Aortic Dissection

主动脉夹层(AD)是一种危及生命的急性综合征。AD发病和进展的病理机制主要与主动脉血管内皮细胞的功能改变、血管平滑肌细胞的表型转化和功能丧失、细胞外基质成分的改变和炎症反应有关。MicroRNA是一类高度保守的非编码RNA分子,可参与多种生物学功能。MiRNA的异常表达可导致不同的心血管疾病,在心血管疾病的发生、发展中发挥重要作用。

Aortic dissection (AD) is a life-threatening acute syndrome. The pathological mechanism of the pathogenesis and progression of AD is mainly related to the functional changes of aortic vascular endothelial cells, phenotypic transformation and loss of function of vascular smooth muscle cells, changes in extracellular matrix components and inflammatory response. MicroRNA is a kind of highly conserved non-coding RNA molecules, which can participate in a variety of biological func-tions. The abnormal expression of miRNA can lead to different cardiovascular diseases and play an important role in the development and progression of cardiovascular diseases.