血清C反应蛋白、白蛋白及其比值在冠心病中的研究进展

Research Progress of Serum C-Reactive Protein, Albumin and Their Ratios in Coronary Heart Disease

冠状动脉粥样硬化性心脏病(简称冠心病)是全球最受关注的健康问题。冠状动脉粥样硬化被认为是一种多因素,多步骤的过程,经研究已证实,炎症和冠状动脉粥样硬化之间存在密切关系,C反应蛋白(C-Reactive Protein, CRP)和白蛋白(Albumin, ALB)在冠状动脉粥样硬化斑块的形成、破裂以及血栓形成,最终引起心肌梗死的整个过程中均发挥至关重要的作用。CRP与ALB比值(ratio of C-reactive protein to albumin, CAR)是一种新型的炎症生物标志物,CAR与冠心病的严重程度和预测冠心病的预后比单独使用CRP和ALB更密切。该文就CRP、ALB、CAR在冠心病发生发展以及评估预后结局方面的作用进行综述,旨在为冠心病患者的诊疗提供一定参考。

Coronary atherosclerotic heart disease (coronary heart disease) is one of the most concerned health problems in the world. Coronary atherosclerosis is considered to be a multi-factor and multi-step process. Studies have confirmed that there is a close relationship between inflammation and coro-nary atherosclerosis. C-reactive protein (CRP) and albumin (ALB) play a crucial role in the whole process of the formation, rupture and thrombosis of coronary atherosclerotic plaques, which even-tually lead to myocardial infarction. The ratio of C-reactive protein to albumin (CAR) is a novel in-flammatory biomarker. CAR is more closely associated with the severity and prognosis of coronary heart disease than CRP and ALB alone. This paper reviews the effects of CRP, ALB and CAR on the occurrence, development and prognosis of coronary heart disease, aiming to provide some refer-ence for the diagnosis and treatment of patients with coronary heart disease.