老年人糖尿病与肌少症关系的研究

Study on the Relationship between Diabetes Mellitus and Sarcopenia in the Elderly

糖尿病是以高血糖为特征的全身代谢性疾病,糖尿病患病人数逐年增多,各种并发症严重影响患者生活质量。肌少症是一种年龄相关性疾病,随病程进展严重威胁老年人身体。研究发现老年人中,糖尿病人群肌少症患病率是正常人群的三倍,与糖尿病相关的肌少症的发生原因可能与胰岛素抵抗、胰岛素分泌不足、代谢紊乱、慢性炎症及糖尿病其他并发症相关,但目前对于肌少症的治疗尚在探索阶段。本文根据国内外文献,对糖尿病合并肌少症的发病机制及相关治疗方法进行综述。

Diabetes is a systemic metabolic disease characterized by hyperglycemia. The number of diabetes patients is increasing year by year, and the quality of life of patients is severely affected by various complications. Sarcopenia is an age-related disease, which is a serious threat to the elderly as the disease progresses. Studies have found that the prevalence of sarcopenia in the elderly population with diabetes is three times that of the normal population. The causes of diabetic sarcopenia may be related to insulin resistance, insufficient insulin secretion, metabolic disorders, chronic inflamma-tion and other complications of diabetes. However, the treatment of sarcopenia is still in the explo-ration stage. Based on the literature at home and abroad, this paper reviews the pathogenesis and treatment of diabetes mellitus with sarcopenia.