期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基质金属蛋白酶-9及其抑制剂在中枢神经系统免疫性疾病中的研究进展

Recent Research on Matrix Metalloproteinase-9 and Its Inhibitors in Central Nervous System Immune Diseases
下载PDF
导出
摘要 中枢神经系统免疫性疾病泛指一类由免疫机制介导的神经系统疾病,其发病机制十分复杂,血脑屏障(blood-brain barrier, BBB)的破坏在其中起着重要的作用。基质金属蛋白酶(matrix metallopro-teinases, MMPs)家族可通过降解基底膜及紧密连接等成分而破坏BBB,近年来研究发现MMP-9及抑制剂组织金属蛋白酶抑制因子-1 (Tissue inhibitor of metalloproteinase-1, TIMP-1)可通过破坏BBB而参与多种中枢神经系统免疫性疾病的疾病进程,并与疾病的严重程度与预后等相关。本文就MMP-9及TIMP-1在几种中枢神经系统免疫性疾病的研究进展做一综述。 Central nervous system immune diseases generally refer to kinds of nervous system diseases me-diated by immune mechanism. Their pathogenesis is very complex, and the destruction of blood- brain barrier (BBB) plays an important role in it. The matrix metalloproteinases (MMPs) family can destroy BBB by degrading basement membrane and tight junctions and other components. In re-cent years, it has been found that MMP-9 and its inhibitor tissue metalloproteinase inhibitor-1 (TIMP-1) take participate in disease process of various central nervous system immune diseases by destroying BBB. MMP-9 and TIMP-1 are related to the severity and prognosis of the disease. This article reviews research progress of MMP-9 and TIMP-1 in several central nervous system immune diseases.
作者 周侣丽 蒋莉
机构地区 重庆医科大学附属儿童医院神经内科 重庆医科大学附属儿童医院
出处 《临床医学进展》 2023年第4期5165-5169,共5页 Advances in Clinical Medicine
关键词 基质金属蛋白酶-9 组织金属蛋白酶抑制因子-1 中枢神经系统免疫性疾病
分类号 R73 [医药卫生—肿瘤]
  • 相关文献

参考文献8

二级参考文献52

  • 1Lee KY, Kim EH, Yamg WS, et al. Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis [J]. J Neurol Sci,2004,220:73-78.
  • 2Lindberg RL, Sorsa T, Tervahartiala T,et al. Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children[J]. Neuropathol Appl Neurobiol,2006,32:304-317.
  • 3Rosenberg GA, Estrada EY, Mobashery S. Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced bloodbrain barrier opening in rodents: Differences in response based on strains and solvents[J]. Brain Res,2007,1133:186-192.
  • 4Lorenzl S, Albers DS, Narr S, et al. Expression of MMP-2, MMP- 9, and MMP-1 and their endogenous counterregulators T1MP-1 and TIMP-2 in postmortem brain tissue of Parkinson's disease[J]. Exp Neurol,2002,178:13-20.
  • 5Guo S, Wang S, Kim WJ, et al. Effects of apoE isoforms on betaamyloid-induced matrix metalloproteinase-9 in rat astrocytes[J]. Brain Res,2006,1111:222-226.
  • 6Yan P,Hu X,Song H,et al. Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ[J]. J Biol Chem,2006,281:24566-24574.
  • 7Ahmed SH, Clark LL, Penninqton UR, et al . Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease[J]. Circulation,2006,113:2089-2096.
  • 8Choi ET, Collins ET, Marine LA, et al. Matrix metalloproteinase-9 modulation by resident arterial cells is responsible for injuryinduced accelerated atherosclerotic plaque development in apolipoprotein E-deficient mice[J].Arterioscler Thromb Vasc Biol, 2005,25:1020-1025.
  • 9Uchima Y, Sawada T, Hira Kawa K. Action of antiprotease on pancreatic cancer cells[J]. JOP, 2007,8:479-487.
  • 10sllchima Y, Sawada T, Nishihara T, et al. Inhibition and mechanism of action of a protease inhibitor in human pancreatic cancer cells[J]. Pancreas,2004,29:123-131.

共引文献608

临床医学进展
2023年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部