肿瘤相关巨噬细胞在胃癌中的研究进展

Research Progress of Tumor-Associated Macrophages in Gastric Cancer

肿瘤相关巨噬细胞在不同因子的作用下可以分化为经典活化型和交替活化型两种表型,两种表型对胃癌细胞的发生、发展发挥相反的作用,其中,M2型能够分泌多种趋化因子,抑制炎性反应的发生,促进血管和淋巴管形成。胃癌是常见的恶性消化道肿瘤,患者整体生存率还较低,因此寻找特异性的能够预测预后的因素,开发新的作用靶点迫在眉睫。鉴于此本文就肿瘤相关巨噬细胞在胃癌中的有关研究进行分析、综述,以期为改善胃癌患者预后,研发新型靶向药物提供新视角。

Tumor-associated macrophages can differentiate into two phenotypes, classical activation and al-ternating activation under the action of different factors, and the two phenotypes play opposite roles on the occurrence and development of gastric cancer cells, among which M2 can secrete a va-riety of chemokines, inhibit the occurrence of inflammatory reactions, and promote the formation of blood vessels and lymphatic vessels. Gastric cancer is a common malignant digestive tract tumor, and the overall survival rate of patients is still low, so it is urgent to find specific factors that can predict prognosis and develop new targets. In view of this, this paper analyzes and reviews the rel-evant research of tumor-associated macrophages in gastric cancer, in order to provide a new per-spective for improving the prognosis of gastric cancer patients and developing new targeted drugs.