尿激酶超时间窗静脉治疗急性脑梗死的研究进展

Research Progress of Intravenous Urokinase in the Treatment of Acute Cerebral Infarction beyond the Time Window of Thrombolysis

急性脑梗死是脑血管病变引起的疾病,具有较高的致死致残率,且发病人数逐年增多,造成了沉重的负担,静脉溶栓是经循证医学认证的有效实现再灌注的措施,但传统的治疗时间窗较窄,只有少数患者符合标准。多模式磁共振可帮助筛选存在缺血半暗带的超时间窗患者,使其从静脉溶栓中获益,本文针对国内外对尿激酶治疗超时间窗急性脑梗死的研究进展进行综述。

Acute cerebral infarction is a disease which is caused by cerebrovascular disturbs. It has a high rate of death and disability. The number of patients is increasing year by year and causing a heavy load. Intravenous thrombolysis is an effective reperfusion measure that is certified by evidence based medicine, but the traditional treatment time window is narrow, and only a few patients meet the standards. Multimode MRI can help to select patient who is beyond therapeutic window but has is-chemic penumbra, and make them get benefit from intravenous thrombolysis. This article reviews the research progress of Urokinase in the treatment of acute cerebral infarction in the ultra-time window.