间充质干细胞治疗克罗恩病肛周瘘管的研究进展

Study Advances in the Treatment of Perianal Fistulizing Crohn’s Disease with Mesenchymal Stem Cells

克罗恩病(Crohn’s disease, CD)是一种肠道慢性进展性炎性疾病,病变以末段回肠及其邻近结肠为主,可累及从口腔至肛周的任一部位,肛周瘘管是克罗恩病的常见并发症,严重影响患者的生活质量。间充质干细胞(Mesenchymal Stem Cells, MSCs)具有免疫调节和抗炎作用,在治疗克罗恩病肛周瘘管方面具有发展潜力。本文将对近年来MSCs用于克罗恩病肛周瘘管的治疗情况进行综述。

Crohn’s disease (CD) is a chronic and progressive inflammatory disease of the intestinal tract. The pathological changes of CD are mainly in the terminal ileum and its adjacent colon, and can affect any part from oral cavity to perianal region. Perianal fistula is a common complication of CD, which seriously affects the quality of life of patients. Mesenchymal stem cell (MSC) has immunomodulatory and anti-inflammatory effects and has a good effect in the treatment of Crohn’s disease anal fistula. This article will review the application of MSCs in the treatment of perianal fistula in Crohn’s disease in recent years.